New morphological risk factors for metastasis to regional lymph nodes in rectal cancer with invasion into the submucosa

AIM to assess prognostic significance of pathologic features T1 rectal carcinoma in relation regional lymph nodes involvement (N+). MATERIAL AND METHODS : surgical specimens (n = 66) from resection for pT1 were investigated. Following prognosticators evaluated: depth submucosal invasion, grade differentiation, lymphovascular invasion (LVI), tumor budding (Bd), poorly differentiated clusters (PDC) and rupture cancer glands (CGR). RESULTS metastases found 13 (19.7%) specimens. LVI was associated lymphatic spread great possibility OR 38.0 95% CI 2.1-670 (p < 0.0001). Tumor high (Bd3) 6.2 1.2-31 0.0001) 0,03) also increased risk node metastases. Depth failed demonstrate significant association with N+. Logistic regression analysis allowed determine as independent factor involvement. CONCLUSION are factors